脊髄の進化に関する発見
Hello everyone, SCIENSPOT is a podcast that shines the spotlight on the latest scientific
technology from Japan.
Your host is REN from SCIEN-TALK.
Today we look at a revolutionary finding from Nagoya University regarding the evolution
of the spinal cord.
We all know that tetrapods, four limbal animals including humans, have two distinct thickened
areas in their spinal cord, cervical enlargement and the lumbar enlargement.
These enlargements exist because controlling limbs requires a massive number of neurons
to manage complex muscles and sharp skin sensation.
For a long time, the consensus was that the fish and snakes which lack limbs also lacked
this spinal enlargement.
It seems intuitive, no limbs, no need for the extra neural processing power.
However, the researchers hypothesized that this view might be too simplistic.
ゼブラフィッシュの脊髄研究
Fish have pectoral and pelvic fins, which are homologous to our arms and legs.
These fins also perform complex, precise movements.
The team wondered even if these spinal regions aren't visibly large to the naked eye, might
the fin-controlling areas still be thickened?
Professor Naoyuki Yamamoto and his team at Nagoya University focused on the zebrafish.
Their first scientific challenge was locating the existing spinal segment responsible for
controlling all five types of fins.
They used advanced techniques, including immunohistochemical straining and tissue clearing, which allowed
them to clearly see the neural pathways deep inside the fish body.
After mapping the neural connections, they systematically created several tissue sections,
very thin slices along the entire length of the spinal cord.
They then measured the physical area of the total spinal cord and crucially the gray matter.
The gray matter is the center of the spinal cord, where most nerve cell bodies are concentrated.
The results were unexpected and highly significant.
They found that the spinal cord area and the gray matter area showed multiple peaks, indicating
the presence of spinal enlargements.
Crucially, these enlargements precisely corresponded to the regions controlling the fins.
The thickened areas were found to be most prominent just behind the start of the fin-controlled
regions aligned with the biologically most important parts of the fin structure, which
are stiffened by fin rays.
But the biggest surprise was this.
The spinal enlargements were present not only for the pectoral and pelvic fins, but also
脊髄の新たな理解
for all the impaired fins.
Every single fin in the zebrafish had a corresponding thickened area in the spinal cord.
This discovery fundamentally changes the definition of the spinal enlargement.
It proves that the traditional view, spinal enlargements equals cervical plasma lumbar
enlargement, was merely a stereotype that didn't fully reflect the true nature of this
structure.
Instead, the original generalized condition in vertebrates, starting with fish, was to
form enlargements corresponding to all fins.
The evolutionary implication is profound.
When vertebrates transitioned to land, only the impaired fins developed into limbs for
locomotion.
Consequently, tetrapods lost the other fins and retained only the two remaining enlargements.
The conclusion is that the familiar spinal enlargements in humans and other tetrapods
進化の洞察
are not unique limb structures, but rather remnant of a more generalized fin-contouring
system inherited from their fish ancestors.
This is a truly groundbreaking insight into our own evolutionary history.
That's all for today's SciencePod.
This podcast is broadcast in both Japanese and English.
I'd love for you to listen to the podcast and post your thoughts with the hashtag SciencePod.
Thank you for listening and see you next time.
