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2026-01-28 03:40

76. Sound is Fast: How Do We Hear Left from Right?

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Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

https://www.nagoya-u.ac.jp/researchinfo/result/2025/12/post-925.html

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サマリー

今日のエピソードでは、耳が音の方向を判断する方法、特に耳間時間差(ITD)について解説されます。日本の研究チームによる新しい研究が、聴覚脳幹における音の定位に関連する神経繊維の超精密な構築方法を明らかにします。脳が音の方向を正確に把握する仕組みについての驚くべき発見が紹介されます。音を聴く過程では、神経繊維が周囲の細胞と積極的にコミュニケーションをとり、音の位置を特定するための微妙な調整を行います。また、音の速さと人間の聴覚がどのように左と右の音を区別するかも探求されます。

音と聴覚の関係
Hello everyone, SCIENSPOT is a podcast that shines a spotlight on the latest scientific technology from Japan.
Your host is REN from SCIEN-TALK.
Today, let's talk about the incredible precision of our ears.
If I snap my fingers on your right side, you know immediately it's coming from the right.
How does your brain know?
This image is the tiny time difference between the sound reaching your right ear versus your left ear.
This is called the interaural time difference, ITD.
Believe it or not, this difference is only a few tens of microseconds.
To calculate this, the nerve signals from both ears must arrive at a specific spot in the brain at the exact same time.
It requires incredible timing precision.
Today, I will explain a new study from a Japanese research team that reveals how the brain builds these super-precise cables.
The research is focused on the auditory brainstem.
Nerve fibers are coated with an insulation layer called a mirroring.
This mirroring acts like a rubber coating on a wire, helping electrical signals travel fast.
In the sound localization circuit, scientists knew that the shape of this mirroring changes depending on the location.
In the tract region, mirroring is long and signals move fast.
In the NL region, this is the processing center, mirroring becomes short and dense to fine-tune the signal speed.
音の方向を知る脳の仕組み
But how does the brain know to change the mirroring structure so perfectly?
The research team made a surprising discovery using chicken brainstems.
They found that the nerve fibers themselves release small chemical packages called vesicles along their length.
Usually, nerves only release these at the end, at the synapse.
But here, they were releasing them along the cable.
To test this, they used a toxin called etent.
This toxin blocks the release of these vesicles.
When they blocked the vesicles, the results were clear.
In the areas where mirroring should be dense and precise, the mirroring failed to form correctly.
They microscope images showed unmirrorinated segments, gaps in the insulation where there shouldn't be any.
This means that nerve fiber isn't just a passive cable.
It actively communicates with surrounding cells by releasing chemicals, telling them exactly how to wrap the mirroring insulation.
By doing this, the nerve fine-tunes its own transmission speed to achieve that microsecond precision needed to locate sound.
This vesicle release mechanism is the secret engineer behind our hearing.
ポッドキャストの紹介
That's all for today's SciencePod.
This podcast is broadcast in both Japanese and English.
I'd love for you to listen to the podcast and post your thoughts with the hashtag SciencePod.
Thank you for listening and see you next time.
03:40

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